我的賬戶 7×24小時客服熱線:400-829-7929 語言:
熱門產品: 原人參二醇,雷公藤甲素,蟲草素,6-姜酚,中藥成分化合物庫
產品分類
在線咨詢
聯系電話:
銷售:
400-829-7929(7*24小時)
028-82633860
028-82633397 
028-
82633165
技術服務和產品定制:
028-82633987
在線服務:  
沈帥 點擊這里給我發消息 
文靜  點擊這里給我發消息
文獻信息

Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells

期刊名:Am J Cancer Res.
文獻編號: PMC4300697
文獻地址: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300697/
發表日期:2014 Dec 15.


Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells

Sung-Lyul Lim, Sang-Yoon Park,  Sukmin Kang,  Dain Park, Sung-Hoon Kim,  Jae-Young Um,  Hyeung-Jin Jang,  Jun-Hee Lee,  Chul-Ho Jeong , Jung-Hee Jang,  Kwang Seok Ahn  and Seok-Geun Lee

Abstract

STAT3 has been recognized as an efficacious drug target for prostate cancer because of its constitutive activation in this fatal disease. We recently identified the root bark of Morus alba Linn. as a potential STAT3 inhibitor among 33 phytomedicines traditionally used in Korea. Morusin, an active compound isolated from the root bark ofMorus alba, has shown anti-oxidant and anti-inflammatory effects. In the present study, we examined whether morusin has a potential as an anti-cancer agent in prostate cancer. We found that morusin suppressed viability of prostate cancer cells, but little effect in normal human prostate epithelial cells. Morusin also reduced STAT3 activity by inhibiting its phosphorylation, nuclear accumulation, and DNA binding activity. In addition, morusin down-regulated expression of STAT3 target genes encoding Bcl-xL, Bcl-2, Survivin, c-Myc and Cyclin D1, which are involved in regulation of apoptosis and cell cycle. Furthermore, morusin induced apoptosis in human prostate cancer cells by reducing STAT3 activity. Taken together, these results suggest that morusin could be a potentially therapeutic agent for prostate cancer by reducing STAT3 activity and inducing apoptosis.

 Morusin purchased from Biopurify Phytochemicals Ltd. (Chengdu, Sichuan, China) 

相關產品
在線客服系統
吉林新11选5开奖结果 乐队的赚钱方式 辽宁35选7 球探体育比分老版本 1o元投资赚钱 河北20选5 1.80星王合击那个赚钱 官方网龙江微乐麻将 原子国货汇凭什么赚钱 欧洲即时赔率哪里查 五分彩 刷粉丝点赞怎么赚钱 辽宁35选7 在新疆做什么才能赚钱 今日竞彩比分推荐 熊猫麻将代理充值平台 单机捕鱼达人8炮版